Cover of: Bioassay of endosulfan for possible carcinogenicity. | National Cancer Institute (U.S.). Division of Cancer Cause and Prevention.

Bioassay of endosulfan for possible carcinogenicity.

  • 100 Pages
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  • English
by
Dept. of Health, Education, and Welfare, Public Health Service, National Institutes of Health, National Cancer Institute, Division of Cancer Cause and Prevention, Carcinogenesis Testing Program , Bethesda, Md
Carcinogens., Pesticides -- Toxico
Other titlesEndosulfan.
SeriesCarcinogenesis technical report series ; no. 62, DHEW publication ; no. (NIH) 78-1312, DHEW publication -- no. (NIH) 78-1312.
The Physical Object
Pagination100 p. in various pagings :
ID Numbers
Open LibraryOL15220360M

Book Govt Pub, Federal: Additional Physical Format: Online version: Bioassay of endosulfan for possible carcinogenicity (OCoLC) Material Type: Government publication, National government publication: Document Type: Book: All Authors / Contributors: National Cancer Institute (U.S.).

Division of Bioassay of endosulfan for possible carcinogenicity. book Cause and Prevention. OCLC Number. Bioassay of endosulfan for possible carcinogenicity (OCoLC) Material Type: Document, Government publication, National government publication, Internet resource: Document Type: Internet Resource, Computer File: All Authors / Contributors: National Cancer Institute (U.S.).

Description Bioassay of endosulfan for possible carcinogenicity. FB2

Division of Cancer Cause and Prevention. A bioassay of technical-grade endosulfan for possible carcino­ genicity was conducted using Osborne-Mendel rats and B6C3F1 mice.

Endosulfan was administered in the feed, at either of two concentra­ tions, to groups of 50 male and 50 female animals of each species.

The time-weighted average high and low dietary concentrations of. Bioassay of endosulfan for possible carcinogenicity by National Cancer Institute (U.S.). Division of Cancer Cause and Prevention. Publication date Topics Carcinogens, Endosulfan, Pesticides Publisher Bethesda, Md.: Dept.

of Health, Education, and Welfare, Public Health Service, National Institutes of Health, National Cancer Institute Pages: National Cancer Institute (). Bioassay of Endosulfan for Possible Carcinogenicity, U. Department of Health, Education and Welfare, Public Health Service, National Institutes of Health, Technical Report Series No.

National Research Council Canada (). Endosulfan: Its Effects on Environmental Quality. NTP. Endosulfan (). Chemical Effects in Biological Systems (CEBS).

Research Triangle Park, NC (USA): National Toxicology Program (NTP). Accessed https://mantic. Bioassay of ICRF for possible carcinogenicity Published: () Bioassay of sulfisoxazole for possible carcinogenicity Published: () Bioassay of estradiol mustard for possible carcinogenicity Published: ().

Bioassay of trisodium ethylenediaminetetraacetate trihydrate for possible carcinogenicity Published: () Bioassay of parathion for possible carcinogenicity Published: (). Endosulfan is not listed as known, probable, or possible carcinogen by the EPA, IARC, or other agencies.

No epidemiological studies link exposure to endosulfan specifically to cancer in humans, but in vitro assays have shown that endosulfan can promote proliferation of human breast cancer cells.

Evidence of carcinogenicity in animals is ein Reference: The role of toxicity in the carcinogenicity of endosulfan.

Reuber MD. Two studies have been undertaken on the toxicity and carcinogenicity of endosulfan, a chlorinated cyclodiene - the NCI Endosulfan Rat Study and the NCI Endosulfan Mouse Study. Histological sections have been examined and the results of this review are based on my by: Reyna L.

Camacho-Morales, José E. Sánchez, in Mushroom Biotechnology, Endosulfan biodegradation by fungi. Endosulfan is an insecticide that is applied extensively to coffee, tea, and cotton crops, among others.

In its commercial form, endosulfan is composed of two stereoisomers, α and β endosulfan, in a ratio. Total endosulfan residue levels in postmortem samples from carcass of poisoned dairy cows were ppm in rumen content &, & ppm in liver, kidney, & muscle tissue, respectively.

Analysis of milk from cows which survived the poisoning revealed level of greater than 1 ppm endosulfan immediately following the intoxication. Endosulfan sulfate was detected in Canadian agricultural soils ranging from not detected ug/kg dy weight(2).

Endosulfan sulfate was detected in 1 out of soil samples from Baltimore, MD in at ppm avg dry wt of all samples(4). It was also detected in 1 out of 43 samples in Macon, GA at ppm avg dry wt of all samples. endosulfan in accord with specifications of the Food and Agricultural Organization of the United Nations (FAO Specification 89/TC/S) [1] with the content of the α-isomer in the range of % and the β-isomer of %.

The α-isomer is asymmetric and. Abstract. Although various approaches to carcinogenesis testing have been proposed [e.

g., Weisburger and Williams (1)] involving short-term in vitro tests and limited or short-term in vivo tests using a tumorigenic endpoint, chronic carcinogenesis bioassay in animals is still the method most commonly used to detect the potential carcinogenicity of chemicals to by: 1.

Endosulfan, endosulfan sulfate, α-endosulfan, and β-endosulfan have been designated as a hazardous substances pursuant to the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA) of (EPA d).

The statutory source for this designation for endosulfan sulfate, α- and. endosulfan isomers of 35 to 37 days at ph and to days at ph bio degradation may be an important fate process with a half- life of 11 weeks for endosulfan sulphate incubated with mixed cultures from a sandy loam soil.

In a controlled environment,losses from the grass andFile Size: KB. No definite conclusion concerning the carcinogenicity of endosulfan was drawn from the bioassay of male rats or male mice because of the abbreviated life spans of these animals.

However, survival among the females of both species was sufficient for meaningful statistical evaluation of the incidence of late developing tumors [39].Cited by: Effect of endosulfan on the testis of growing rats. Bulletin Environ Contamination ToxicolSinha N, Narayan R, Shanker R, Saxena DK.

Endosulfan-induced biochemical changes in the testis of rats. Veterinary and Human Toxicol(b) U.S. National Cancer Institute () Bioassay of Endosulfan for Possible. Endosulfan is an off-patent organochlorine insecticide and acaricide that is being phased out globally.

Endosulfan became a highly controversial agrichemical [1] due to its acute toxicity, potential for bioaccumulation, and role as an endocrine e of its threats to human health and the environment, a global ban on the manufacture and use of endosulfan was CAS number: The project is made possible by our Sponsors and by PAN general funds.

We need your support to maintain and improve this system. including carcinogenicity, reproductive and developmental toxicity, neurotoxicity, and acute toxicity.

Regulatory. Any underlined term with a book icon has additional information. ENDOSULFAN 3EC Page 2 of 10 DIRECTIONS FOR USE RESTRICTED USE PESTICIDE It is a violation of Federal Law to use this product in a manner incon-sistent with its labeling. Do not apply this product in a way that will contact workers or other persons, either directly or through drift.

Only protected handlers may be in the area during application. Carcinogenicity Assessment (II.) not evaluated.

Details Bioassay of endosulfan for possible carcinogenicity. FB2

Chronic Health Hazard Assessments for Noncarcinogenic Effects. I.A. Reference Dose for Chronic Oral Exposure (RfD) Substance Name — Endosulfan CASRN — Last Revised — 10/01/ The oral Reference Dose (RfD) is based on the assumption that thresholds exist for certain toxic.

The objective of current investigation was to determine the genotoxic and cytotoxic potential of Endosulfan (EN) and Lambda-cyhalothrin (LC); individually and in combination. 3-(4,5-Dimethylthiazolyl)-2,5-Diphenyltetrazolium Bromide (MTT) assay was utilized to determine cytotoxicity, while two mutant histidine dependent Salmonella strains Cited by: 6.

Two studies have been undertaken on the toxicity and carcinogenicity of endosulfan, a chlorinated cyclodiene - the NCI Endosulfan Rat Study and the NCI Endosulfan Mouse Study.

India has agreed to phase out use of Endosulfan by and all existing stock of the pesticide in the country that is past its expiry date, government said today. WHAT IS ENDOSULFAN???.

Download Bioassay of endosulfan for possible carcinogenicity. FB2

A toxic organochlorine pesticide of moderate mammalian toxicity which doesn’t accumulate in the tissues of man or animals to any significant extent. But undiluted Endosulfan is slowly and incompletely absorbed in the GIT of warm blooded animals. In INDIA, Hindustan Insecticide Lmtd is the producer of Endosulfan.

CONTINUING DISASTER OF ENDOSULFAN IN KASARGOD AND KANNUR DISTRICTS OF KERALA Abstract Between andmore t villagers of Kasargod district in Kerala, India have been exposed to endosulfan, a persistent organic pesticide, sprayed on the cashew plantations owned by the Plantation Corporation of Kerala.

Author: Endosulfan. Endosulfan is a central nervous system stimulant and produces effects similar to other cyclodienes (Hayes & Laws, ). It can cause headache, fainting, foaming at the mouth, agitation, repeated convulsions of an epileptic-like nature, incontinence, impaired consciousness, breathing difficulty, cyanosis, malaise, dizziness, nausea and vomiting, weakness, confusion.

BRIEF OVERVIEW OF ENDOSULFAN REVIEW Endosulfan is an insecticide which has been widely used in Australia for over 30 years.

The agricultural industry and State agricultural authorities advise that endosulfan is extremely important to agriculture, and for some crop/pest situations there are no alternatives at all orFile Size: 58KB.

What's up with endosulfan? Lately, we have received many questions about endosulfan, mainly on which products and uses are still registered. There is a lot of confusion right now. We'll try to answer the "who, what, where, when, why" so we are all on the same page.Endosulfan definition is - a toxic crystalline chlorinated insecticide and acaricide C9H6Cl6O3S used especially on food crops.Endosulfan is an insecticide and acaricide that is not approved for use in the EU.

It has a low aqueous solubility and is volatile. Based on its chemical properties it may have a tendency to leach to groundwater. Endosulfan is moderately persistent in soil but does not tend to persist in water systems.

It is highly toxic to mammals, a.